Veterinary and Animal Sciences
Turkish Journal of Veterinary and Animal SciencesThe Effect of ATP-Dependent Potassium Channel Blocker, Glimeprid, on the Arrhythmias Observed Following Ischemia and Reperfusion in Anesthesized Rats
Kafkas Üniveritesi Veteriner Fakültesi Fizyoloji Bilim Dalı, Kars-TÜRKİYE
Istvan LEPRAN, Julius Gy PAP
Department of Pharmacology, Albert Szent-Györgyi Medical University Szeged, HUNGARY
Abstract: In recent years, it has been discussed intensively whether the potassium channel openers or blockers have antiarrhythmic effect during ischemia and reperfusion. Although there are many in vitro studies suggesting the potassium channel blokers especial-ly glibenclamide have antiarrhythmic effect, there is a very few in vivo expertiment to support the same result. In the present study, left arteria coronaria descendence (LAD) was ligated in 6min and following reperfusion was made by relasing the ligature. ECG and arterial blood pressure were recorded during the ischemia and reperfusion. The heart rate, the length of arrhythmia, the score of arrhythmia and the number of survived animals at the and of 6 min of reperfusion were calculated. Glimeprid (1mg/kg) increased the survival rate of the animals (%75 / %112 in control) and decreased) the incidence of fibrilation (%43/%87 in control. There have not been found significant different effect of the same dose (2,5mg/kg/100ul) of glimeprid and glibenclamide on the incidence of ventricular fibrillation, but the survival rate was higher(%82/%47 in glimeprid treated group), in glibenclamide treated group. There was no relation between the incidence of arrhythmias and the arterial pressure or heart rate. In conclusion, as earlier report-ed to the same effect of lgibenclamide, the defibrillatory and dose dependent action of glimeprid on the ischemia and reperfusion arrhythmias were also observed by this study.
Key Words: Heart-Ischemia-Reporfusion-Arrhythmias-glimeprid
Turk. J. Vet. Anim. Sci. 1998; 22: 247-254.
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