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Turkish Journal of Medical Sciences

Genotoxic Evaluation of the Antibacterial Drug, Ciprofloxacin, in Cultured Lymphocytes of Patients with Urinary Tract Infection

Mevlit İKBAL1, Hasan DOĞAN1, Hatice ODABAŞ2, İbrahim PİRİM1
1Department of Medical Genetics, Faculty of Medicine, Atatürk University,
25240 Erzurum - Turkey
2Department of Internal Medicine, Faculty of Medicine, Atatürk University,
25240 Erzurum - Turkey

Abstract: Ciprofloxacin is a quinolone carboxylic acid derivative and is commonly used in medicine. The genotoxicity of ciprofloxacin was evaluated in cultured human peripheral blood lymphocytes in patients with urinary tract infection. Sister chromatid exchange (SCE), mitotic index (MI) and replicative index (RI) were measured before and after ciprofloxacin therapy. Our results showed that SCE frequency significantly increased after ciprofloxacin therapy (P < 0.001), but MI and RI decreased (P < 0.001). The results of this study suggest that clinical therapy using ciprofloxacin may have a moderate genotoxic potential.

Key Words: Ciprofloxacin, sister chromatid exchange, mitotic index, replicative index

Turk J Med Sci 2004; 34(5): 309-313.
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Other articles published in the same issue: Turk J Med Sci,vol.34,iss.5.