Turkish Journal of Medical SciencesHemodynamic Changes After Aortopulmonary Separation
M. Kemal IRMAK
1Department of Physiology, Faculty of Medicine, İnönü University, Malatya; 2Department of Histology and Embryology, Gülhane Military Medical Academy, Ankara; 3Department of Histology and Embryology, Faculty of Medicine, Afyon Kocatepe University, Afyon - Turkey
Abstract: The neural crest origin of the aortopulmonary septum has led us to investigate the septum. We designed the present study to assess the hemodynamic changes following aortopulmonary separation in the rat. We freed the ascending aorta from the pulmonary artery by blunt dissection and placed aluminium foil between them in anesthetized, ventilated, open-chest animals and found that the procedure resulted in a slight but significant increase in systolic and diastolic blood pressure and in an insignificant elevation of the heart rate. The hemodynamic deterioration observed after the separation process might be a result of a possible function of the aortopulmonary septum on blood pressure regulation.
Key Words: Aortopulmonary septum, blood pressure, rat
Turk J Med Sci 2003; 33(3): 167-170.
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Other articles published in the same issue: Turk J Med Sci,vol.33,iss.3.