Turkish Journal of Medical SciencesBcl - 2 Expression in Carcinoma of the Uterine Cervix and its Relationship with Prognostic Variables
Orhan S. AKSAKAL2
Emel Ebru PARLAKYİĞİT2
Departments of 1Histopathology, 2Gynecology and Obstetrics, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara - TURKEY
Abstract: Objective: The aim of this study was to evaluate the importance of the apoptotic activity of squamous cell carcinoma of the cervix and Bcl-2 expression. Materials and Methods: Twenty-seven women with cervical squamous cell carcinoma, admitted to our unit between 1996 and 1998, were reviewed. Patients were classified according to staging and grading systems. Bcl-2 protein material was investigated by immunohistochemistry (streptoavidin, biotine, alkaline phosphatase technique). Results: After immunohistochemical staining, 12 of the 27 cases stained positively (44%). There was a correlation between the grade and staining percentage. We found no significant relationship with stage and staining intensity. Conclusions: Bcl-2 could be used as a marker for blocking well-programmed cell death in low grade cases.
Key Words: Cervical carcinoma, genital tract tumors, Bcl-2
Turk J Med Sci 2001; 31(5): 401-404.
Full text: pdf
Other articles published in the same issue: Turk J Med Sci,vol.31,iss.5.