Turkish Journal of Chemistry

Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines
Ali RAMAZANI¹, Kourosh DASTANRA¹, Fatemeh ZEINALI NASRABADI¹,
Zahra KARIMI¹, Morteza ROUHANI², Mehdi HOSSEINI¹
¹Department of Chemistry, University of Zanjan, PO Box 45195-313, Zanjan-IRAN
e-mail: aliramazani@yahoo.com
²Young Researchers Club, Zanjan Branch, Islamic Azad University, Zanjan-IRAN

Abstract: Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2-oxo-2-phenylacetaldehyde and a secondary amine in the presence of silica nanoparticles, proceeds smoothly at room temperature to afford ketoamide derivatives in high yields.

Key Words: Silica nanoparticles, multicomponent reaction, isocyanide, 2-oxo-2-phenylacetaldehyde, secondary amine, iminium ion

Turk. J. Chem., 36, (2012), 467-476.
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Other articles published in the same issue: Turk. J. Chem.,vol.36,iss.3.