Turkish Journal of ChemistrySynthesis and antimicrobial activities of some bridged bis-benzimidazole derivatives
Ayşe Nilay ÖNGANER3
1Department of Chemistry, Faculty of Arts and Sciences, İnönü University,
2Department of Chemistry, Faculty of Education, Adıyaman University,
3Department of Biology, Faculty of Arts and Sciences, Fırat University,
Abstract: Some bis-benzimidazoles derivatives bearing allyl, crotyl, cinammyl, furfuryl, and thenyl groups were synthesized and their in vitro antimicrobial activity determined against gram-positive and gram-negative bacteria, and fungi by disk-diffusion method. The structures of all new compounds were identified by 1H-NMR, 13C-NMR, and FT-IR spectroscopic techniques and elemental analysis. All the compounds synthesized in this work were examined for their in vitro antimicrobial activities against gram-positive (Staphylococcus aureus and Bacillus megaterium) and gram-negative bacteria (Klebsiella pneumoniae and Escherichia coli), and the yeasts like fungi (Candida globrata and Candida tropicalis). Compared to the reference substances, Cefozine and nystatin, most of the compounds showed high antibacterial and antifungal activities against studied strains with inhibition zones between 8 and 28 mm.
Key Words: Bis-benzimidazole derivatives, antibacterial activity, antifungal activity
Turk. J. Chem., 35, (2011), 561-571.
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Other articles published in the same issue: Turk. J. Chem.,vol.35,iss.4.