Turkish Journal of ChemistrySynthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/ nonsubstituted acetophenone) hydrazone
Mahmut ÜLGER3, Gürol EMEKDAŞ3, Mustafa Fethi ŞAHİN2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin University,
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University,
3Department of Medical Microbiology, Faculty of Medicine, Mersin University,
4Health Services Vocational School, Mersin University,
Synthesis and in vitro antimycobacterial activities of novel
nonsubstituted acetophenone) hydrazone
Abstract: The difficulty in managing tuberculosis includes the prolonged duration of the treatment, the emergence of drug resistance, and coinfection with HIV/AIDS. Tuberculosis control requires new drugs that act on novel drug targets to help in combating resistant forms of Mycobacterium tuberculosis and reduce the treatment duration. For this purpose, 6-substituted-3(2H)-pyridazinone-2-acetyl-2- (substituted/nonsubstituted acetophenone) hydrazone derivatives were synthesized and their structures were elucidated by elemental analyses, IR, and 1H-NMR. The in vitro antimycobacterial activities of synthesized compounds 5a-l were determined by the agar proportion method against Mycobacterium tuberculosis H37Rv. Among the target compounds, 5b and 5f exhibited the best antimycobacterial activity, with a MIC value of 5 m g/mL.
Key Words: 3(2H)-Pyridazinone, acetophenone hydrazone, antimycobacterial activity, antitubercular drugs
Turk. J. Chem., 35, (2011), 331-339.
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Other articles published in the same issue: Turk. J. Chem.,vol.35,iss.2.