Turkish Journal
of
Chemistry
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Turkish Journal of Chemistry
Synthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/ nonsubstituted acetophenone) hydrazoneMahmut ÜLGER3, Gürol EMEKDAŞ3, Mustafa Fethi ŞAHİN2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin University,
33169, Mersin-TURKEY
e-mail: utkusemra@mersin.edu.tr
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University,
06330, Ankara-TURKEY
3Department of Medical Microbiology, Faculty of Medicine, Mersin University,
33169, Mersin-TURKEY
4Health Services Vocational School, Mersin University,
33020, Mersin-TURKEY
Synthesis and in vitro antimycobacterial activities of novel
6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/
nonsubstituted acetophenone) hydrazone
Abstract: The difficulty in managing tuberculosis includes the prolonged duration of the treatment, the emergence of drug resistance, and coinfection with HIV/AIDS. Tuberculosis control requires new drugs that act on novel drug targets to help in combating resistant forms of Mycobacterium tuberculosis and reduce the treatment duration. For this purpose, 6-substituted-3(2H)-pyridazinone-2-acetyl-2- (substituted/nonsubstituted acetophenone) hydrazone derivatives were synthesized and their structures were elucidated by elemental analyses, IR, and 1H-NMR. The in vitro antimycobacterial activities of synthesized compounds 5a-l were determined by the agar proportion method against Mycobacterium tuberculosis H37Rv. Among the target compounds, 5b and 5f exhibited the best antimycobacterial activity, with a MIC value of 5 m g/mL.
Key Words: 3(2H)-Pyridazinone, acetophenone hydrazone, antimycobacterial activity, antitubercular drugs
Turk. J. Chem., 35, (2011), 331-339.
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Other articles published in the same issue: Turk. J. Chem.,vol.35,iss.2.