Turkish Journal
of
Chemistry
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Turkish Journal of Chemistry
Synthesis and Antimicrobial Evaluation of Some New 2-(2-(p-chlorophenyl) benzimidazol-1-yl methyl)-5-substituted amino-[1,3,4]-thiadiazolesNurten ALTANLAR2, Süheyla ÖZBEY3
1Department of Pharmaceutical Chemistry, Pharmacy Faculty , Ankara University
06100 Tandoğan, Ankara-TURKEY
e-mail: kilcigil@pharmacy.ankara.edu.tr
2Department of Microbiology, Pharmacy Faculty, Ankara University
06100 Tandoğan, Ankara-TURKEY
3Department of Physics Engineering, Hacettepe University
06532, Beytepe, Ankara-TURKEY
Abstract: Some 2-(2-(p-chlorophenyl)benzimidazol-1-ylmethyl)-5-substituted amino-[1,3,4]-thiadiazoles were synthesized and their in vitro antimicrobial activities were tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans and Candida krusei. Compounds 1b and 12b which possess remarkable activity against C. albicans and marginal activity against C. krusei were found to be the most active compounds in this series. Single crystal X-ray diffraction analysis was performed for compound 8b.
Key Words: Benzimidazoles, thiadiazoles, antimicrobial activity, X-ray
Turk. J. Chem., 29, (2005), 153-162.
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Other articles published in the same issue: Turk. J. Chem.,vol.29,iss.2.