Turkish Journal of ChemistryA Convenient Synthesis of 3,6-Disubstituted-1,4-Dihydro-[1,2,4,5]Tetrazines and Preparation of New Acetic Acid Derivatives Containing 5-Oxo-4-Phenylamino- 4,5-Dihydro-[1,2,4]Triazole
Karadeniz Technical University, Department of Chemistry, 61080, Trabzon-TURKEY
Abstract: A series of compounds 8a-e, was synthesized by condensation of compounds 7a-e with ethyl bromoacetate. The treatment of compounds 8a-e with hydrazine hydrate afforded the corresponding hydrazide derivatives (9a-e). Subsequently, compounds 9a-e were converted to alkylidene hydrazides (10a-e). Moreover, upon heating in the presence of carboxylic acids, compounds 9a-e unexpectedly gave 1,4-dihydro-[1,2,4,5]tetrazine derivatives (11a-e).
Key Words: Conformer, geometrical isomer, ethyl bromoacetate, imine bond, 5-oxo-[1,2,4]triazole, [1,2,4,5]tetrazine
Turk. J. Chem., 28, (2004), 311-324.
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Other articles published in the same issue: Turk. J. Chem.,vol.28,iss.3.