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Turkish Journal of Chemistry

Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the Controlled Release of Cyclic Oligopeptide

Bashir AHMAD1, Shumaila BASHIR1, Shams-un NISA2, M. B. HUGLIN3
1Department of Pharmacy University of Peshawar, Peshawar-25120, PAKISTAN
2Department of Pharmacy and Jinnah College for Women, University of Peshawar,
Peshawar-25120, PAKISTAN
3Institute of Material Research and Chemistry, Salford University, Manchester, UK.
e-mail: bashirdr2001@yahoo.com

Abstract: Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent. The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer. The reactivity ratios r1 = 0.045 and r2 = 3.07 for VP and HEMA indicate that HEMA is more reactive than VP in the reaction. Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.

Key Words: N-vinyl-2-pyrrolidone, 2-hydroxyethyl methacrylate, Hydrogels, Drug release

Turk. J. Chem., 28, (2004), 279-286.
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Other articles published in the same issue: Turk. J. Chem.,vol.28,iss.3.